factor XIII

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Definition

Noun: 1. A clotting factor: A substance in blood plasma that is essential for the final stage of blood clot formation. It is activated by thrombin and works to strengthen and stabilize a fibrin clot.

Usage
  • Factor XIII is a specific protein (a clotting factor) in the blood.
  • A deficiency in Factor XIII can lead to a serious bleeding disorder.
  • Thrombin catalyzes the conversion of Factor XIII into its active enzyme form.
Examples
  • The doctor ordered a test to measure the patient's Factor XIII levels.
  • Factor XIII deficiency is a rare but severe condition.
  • In the coagulation cascade, Factor XIII acts after fibrin has been formed.
Advanced Usage
  • Activated Factor XIII (Factor XIIIa): The enzymatically active form of the protein, also known as or . It creates covalent bonds between fibrin strands.
    • The active form, Factor XIIIa, cross-links the fibrin polymer to form a stable clot.
Variants and Related Words
  • Fibrin-stabilizing factor: Another name for Factor XIII, describing its function.
  • Fibrinase: An older term for the activated form (Factor XIIIa).
  • Coagulation factor: The general category to which Factor XIII belongs.
Synonyms
  • Fibrin-stabilizing factor
  • (When activated): Fibrinase
Notes
  • Factor XIII is often written with Roman numerals. It is one of the thirteen essential coagulation factors (I through XIII).
  • Its primary role is not to initiate clotting but to stabilize the clot, preventing premature breakdown.
Noun
  1. in the clotting of blood thrombin catalyzes factor XIII into its active form (fibrinase) which causes fibrin to form a stable clot

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